• Among the isoforms of heme oxygenases

  2022-01-03

  

  Among the 3 isoforms of heme oxygenases (HO-1, HO-2, and HO-3), HO-1 expression is inducible, and it catalyzes the degradation of heme to biliverdin, carbon monoxide (CO) and free Fe. The Fe is then stored in ferritin, limiting its ability to participate as a catalyst through the Fenton reaction and

• Taken together our results indicate that HSF

  2022-01-03

  

  Taken together, our results indicate that HSF1 and NRF2 reciprocally regulate HO-1 expression. Although each of HSF1 and NRF2 controls a distinct cytoprotective pathway, mounting evidence points that they engage in crosstalk [15,22]. The protein-protein interaction between HSF1 and NRF2 may be inter

• In our previous study we

  2022-01-03

  

  In our previous study, we designed and synthesized compounds of A series from the starting material 4-hydroxy-3-methoxycinnamic 74 (ferulic acid). These compounds with R group being amino acid residues, fatty acyl group and sulfuryl group showed moderate HDAC inhibition and in vitro antitumor poten

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