• Some clinical reports have suggested that galanin has a

  2022-05-07

  

  Some clinical reports have suggested that galanin has a role in the neurobiology of mood disorders [[6], [7], [8], [9], [10]]. In behavioral studies, contradictory results have been reported [11,12]. For example, systemic administration of non-selective galanin receptor agonists, such as galmic [13]

• Several small molecules such as erastin

  2022-05-07

  

  Several small molecules, such as erastin and RSL3, are reported to induce ferroptosis in both normal and cancer Fmoc-Val-OH australia [21,22]. We confirmed that erastin-induced growth inhibition is an ideal ferroptosis model for cardiomyocytes. The erastin inhibits the growth of H9c2 cells in a Fe-

• br Materials and methods br Results and discussion In

  2022-05-07

  

  Materials and methods Results and discussion In order to identify genes required for photoautotrophic growth, we screened a random insertion mutant library of Synechocystis 6803 and obtained many mutants with impaired photoautotrophic growth. About 6000 random insertion colonies of the mutant

• Liver and muscle isozymes have

  2022-05-07

  

  Liver and muscle isozymes have been found in vertebrate tissues [2], [5], [6]. The liver FBPase is recognized as a regulatory enzyme of gluconeogenesis. The muscle isozyme participates in the glycogen synthesis from lactate and in the regulation of glycolysis [7], [8], [9]. The basic difference betw

• br Conclusion Discovery of an ideal orally active antithromb

  2022-05-07

  

  Conclusion Discovery of an ideal orally active antithrombotic drug has remained elusive till date. Research efforts in this direction led to the discovery of numerous coagulation enzyme inhibitors including various thrombin and FXa inhibitors. Several preclinical studies have highlighted the impo

• The current study aimed to

  2022-05-06

  

  The current study aimed to understand the roles and the underlying mechanisms of XIST in LSCC, by focusing on the regulation by miR-124-3p, which was previously identified as a target of XIST [12]. We found that the XIST expression is positively correlated with the stages of LSCC in patients. Knockd

• The first wave of cells infiltrating heart

  2022-05-06

  

  The first wave of Suramin hexasodium salt infiltrating heart shortly after MI is composed mainly of neutrophils, with the highest number on the first day after ischemic episode [101]. These cells are recruited via C-X-C motif chemokine ligand-2 (CXCL-2)- and CXCL-5-mediated chemotaxis. Both chemoki

• br Consequence physiological function of ROS dependent inhib

  2022-05-06

  

  Consequence/physiological function of ROS-dependent inhibition of GSNOR Plants response to environmental changes induced by abiotic and biotic factors by enhanced accumulation of ROS resulting in temporary imbalance of the cellular redox homeostasis. This as oxidative stress/burst termed event tr

• br GSNOR regulates SA synthesis and SA signalling

  2022-05-06

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic dormin (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistance, l

• br Materials and methods br

  2022-05-06

  

  Materials and methods Results Human adipocytes, differentiated from fibroblastic preadipocytes in culture, were incubated with IL-33 for either 3 or 24 h to examine acute and prolonged responses to the cytokine. Low, medium and high concentrations of IL-33 were employed. IL-33 had no signific

• There is abundant literature about

  2022-05-06

  

  There is abundant literature about different functional aspects of the cannabinoid system (Badal et al., 2017, Balenga et al., 2011, Henderson-Redmond et al., 2016, Nair et al., 2015); however, not a great deal is known about the mechanism by which ethanol impacts its function in connection to the

• br Materials and methods br Results br Discussion A

  2022-05-06

  

  Materials and methods Results Discussion A synoptic review of these cases will be given. In Case 1 the process presented in a photodistributed fashion in a 79-year-old woman; while the infiltrate was atypical, it was non-effacing with polyclonal molecular studies. The disease eventually res

• The negative impact that dimers present in gp preparations

  2022-05-06

  

  The negative impact that dimers present in gp120 preparations have on overall gp120 affinity for CD4i ligands, mainly by affecting the on-rate, was addressed in this report. Indeed, when his(6)-tagged gp120 proteins, purified with nickel beads (before FPLC, containing gp120 dimers) were used to meas

• br Material and methods br Result br Discussion

  2022-05-06

  

  Material and methods Result Discussion The female with well-differentiated endometrial cancer, especially those in the reproductive age have a strong desire to preserve fertility. Therefore, conservative medical treatment with progestin is widely used in the clinic. However, up to 30% of pa

• br Material and methods br Results br Discussion Neurosteroi

  2022-05-06

  

  Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new SM-164 with different structures have been synthesized in order to cr

15862 records 425/1058 page Previous Next First page 上5页 421422423424425 下5页 Last page