• The influence of climate and rainwater on

  2018-10-25

  

  (2) The influence of climate and rainwater on the site: Located at the center of Guanzhong Basin, Xi\'an is adjacent to the Weihe River and Bashui River to its north and east respectively. Its terrain inclines from southeast to northwest with an altitude of around 400m. Located in a warm temperate z

• In its effect on enhancing differentiation of a large variet

  2018-10-24

  

  In its effect on enhancing differentiation of a large variety of human pluripotent stem cells, the effect of DMSO was thought to be mediated by causing an exit of the pluripotent cells from the cell cycle and greater effectiveness of differentiation factors in G1 (Chetty et al., 2013). However, in o

• General methylation states appeared to be comparable between

  2018-10-24

  

  General methylation states appeared to be comparable between iPSC-derived DA neurons and primary embryonic mdDA neurons (r = 0.85), indicating that our in-vitro-generated DA neurons widely adopted the epigenetic signature of their primary counterparts. Nonetheless, we found several thousand genes hy

• Here we started to address to what extent GFAP ventricular

  2018-10-24

  

  Here, we started to address to what extent GFAP+ ventricular cells, denoted as ependymoglia cells (Parish et al., 2007), within and outside of the constitutively active niches are different from each other in the newt telencephalon. We define two different types of ependymoglia cells, which display

• Y a selective Rho associated kinase ROCK

  2018-10-24

  

  Y-27632, a selective Rho-associated kinase (ROCK) inhibitor, is known to facilitate hESC/hiPSC culture growth by diminishing dissociation-induced apoptosis (Ohgushi et al., 2010; Watanabe et al., 2007). We therefore compared doxycycline- and Y-27632-mediated hESC survival by the colony-forming assay

• br Introduction Pluripotent stem cells can generate

  2018-10-24

  

  Introduction Pluripotent stem cells can generate all cell types of the body and hold great potential for transplantation medicine and the study of early development. Pluripotency arises in the inner cell mass of blastocyst-stage embryos during formation of the epiblast, and both human and mouse b

• It is thought that a

  2018-10-24

  

  It is thought that a better understanding of the molecular and cellular mechanisms that regulate the emergence and maintenance of long-term repopulating hematopoietic stem apoptosis pathway (HSCs) during embryonic development would aid in the development of optimal protocols to generate such cells

• Owing to the colocalization between mitochondria and the

  2018-10-24

  

  Owing to the colocalization between mitochondria and the germ plasm of some animals, models whereby the Balbiani body selects the healthiest mitochondria for the next generation have been proposed (Cox and Spradling, 2003; Pepling and Spradling, 1998). Early as well as more recent studies thus exami

• Chemotherapy is a standard treatment for

  2018-10-24

  

  Chemotherapy is a standard treatment for patients with advanced disease, including nonresectable, recurrent, or metastatic tumors. Due to chemoresistance, the majority of patients die within three years (Papaspyrou et al., 2011). Indeed, cisplatin and other platinum-based therapies do not present cl

• br Main Text br Acknowledgments br

  2018-10-24

  

  Main Text Acknowledgments Main Text Acknowledgments Introduction Pluripotent stem purchase abk (PSCs) are defined by their ability for self-renewal and the capacity to differentiate into cells of the three embryonic germ layers: ectoderm, endoderm, and mesoderm (Thomson et al., 1998)

• The present study showed that transplantation of iBAs and

  2018-10-24

  

  The present study showed that transplantation of iBAs and dBAs markedly reduced diet-induced obesity, dyslipidemia, and insulin resistance in mice (Figures 2, 6, and 7). The dBAs controlled insulin resistance in an UCP1-dependent fashion, strongly suggesting the UCP1-mediated energy expenditure as t

• The inhibition of differentiation has been

  2018-10-24

  

  The inhibition of differentiation has been considered to play a role in many types of tumor development through maintenance of the proliferating progenitor cell state. Previous studies demonstrated that the knockdown of EWS-FLI1 in Ewing sarcoma cell lines results in osteogenic, adipogenic and chond

• Our analysis revealed that mTOR inhibitors

  2018-10-24

  

  Our analysis revealed that mTOR inhibitors added alone to SF-defined medium can induce mesendoderm, and our follow-up studies confirmed that rapamycin enhances the formation of HE and blood progenitors. Ten-point dose curves revealed a bimodal effect where rapamycin at low concentrations mildly enha

• To gain insight into the role of FA proteins

  2018-10-24

  

  To gain insight into the role of FA proteins during development and understand the origin of HSPC deficits, we recently investigated fetal hematopoietic function in a murine model of FA, observing quantitative hematopoietic deficits at embryonic day 14.5 (E14.5) (Kamimae-Lanning et al., 2013). This

• br Results br Discussion Control of cell cycle

  2018-10-24

  

  Results Discussion Control of cell-cycle progression has been linked to the regulation of self-renewal and cell-fate determination in ESCs (Pauklin and Vallier, 2013; Singh et al., 2015; White and Dalton, 2005). It has been reported that the length of the G1 phase defines the capacity of multi

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