• Given the recognized effects of bisphosphonates in

  2019-05-06

  

  Given the recognized effects of bisphosphonates in metastatic breast cancer [14,15] and that potential anticancer effects have been demonstrated in preclinical [16], translational [17], patients with cancer therapy-induced bone loss [18] and salinomycin based-studies [19,20] a number of clinical tri

• br Materials and methods This

  2019-05-06

  

  Materials and methods This study included WCD patients with high risk of SCD but did not meet the eligibility criteria for immediate bms-708163 of an implantable cardioverter defibrillator (ICD). Current guidelines endorse indications for WCD therapy [5]. Patients with low left ventricular eject

• Notably it is also reported that changes in

  2019-05-06

  

  Notably, it is also reported that changes in lipoprotein lipase (LPL) activity, HSL activity, and cAMP accumulation in WAT and BAT after ethanol exposure differ depending on the dose and route of ethanol exposure and tissue type. Moreover, a recent study also found that chronic feeding plus alcohol

• The Cl HCO anion exchanger AE is

  2019-05-06

  

  The Cl−/HCO3− anion exchanger 2 (AE2) is found on cholangiocytes and regulates intracellular pH homeostasis and stimulates bicarbonate secretion. Previous reports have revealed that PBC patients show decreased biliary AE2 expression, and researchers hypothesized that this decrease in AE2 histamine-1

• br Discussion We were interested in knowing whether patients

  2019-05-05

  

  Discussion We were interested in knowing whether patients who were discharged before ANC recovery did well because they were younger, had better PS, or more likely to be in CR than patients who were not discharged before ANC recovery. However while patients with better PS (but not age) were more

• br Discussion Chronic myelogenous leukemia CML is

  2019-05-05

  

  Discussion Chronic myelogenous leukemia (CML) is a clonal disorder involving the pluripotent stem cell and is consistently associated with the BCR-ABL1 fusion gene located on the Philadelphia chromosome [1]. The disease typically evolves in 3 distinct clinical stages: chronic and accelerated phas

• br Discussion In this pilot

  2019-05-05

  

  Discussion In this pilot study, we report that sequential treatment of low dose clofarabine and lenalidomide is safe and feasible for elderly patients with high risk MDS and AML. Only one subject developed dose limiting toxicity (liver dysfunction) from lenalidomide consolidation therapy. Pre-tre

• En Argentina previamente al golpe militar tambi

  2019-05-05

  

  En Argentina, previamente al golpe militar, también reinaba un gobierno democrático cada vez más represivo. El mismo día del retorno de Juan Domingo Perón después de larguísimos años de proscripción, el enfrentamiento entre los principales grupos de las distintas tendencias al interior del peronismo

• With respect to the ST elevation in the precordial lead

  2019-05-04

  

  With respect to the ST elevation in the precordial lead, Antzelevitch et al. demonstrated that this can be an DIG-11-dUTP of early repolarization or J-wave caused by transient outward current (Ito)-mediated transmural differences in the early phases of the action potential. BS is an inherited disea

• br The Global Burden of Disease

  2019-05-04

  

  The Global Burden of Disease Study notes a substantial decrease in long-established global health threats such as communicable diseases and malnutrition, while underscoring the rise in non-communicable diseases and years lived with potentially disabling illnesses and injuries. One important but la

• More than structural haemoglobin variants have been describe

  2019-04-30

  

  More than 900 structural haemoglobin variants have been described. Of these more than 100 show high oxygen affinity [2]. Erythrocytosis caused by Hb Ypsilanti was first described in 1967 [3], and the mutation results in substitution of amino propyl (β99 Asp→Tyr) involved in the stability of the qua

• br Introduction Incidence of oral cancers accounts for of

  2019-04-30

  

  Introduction Incidence of oral cancers accounts for ∼3% of all malignancies. Oral squamous cell carcinoma (OSCC) accounts for >95% of all malignancies in the oral cavity, and it is the fifth leading cause of cancer death in the male population in Taiwan. OSCC is treated mainly with surgery. Post

• Successful and safe catheter ablation is

  2019-04-30

  

  Successful and safe catheter ablation is facilitated by an appreciation for anatomical particularities and surgical details. Morphological analysis of clinically documented VT is also important. In these patients, VT usually shows a left bundle branch block-like QRS morphology and inferior frontal p

• Definida pelo Estado como crit rio inicial para o

  2019-04-29

  

  Definida pelo Estado como critério inicial para o andamento das reivindicações quilombolas por reconhecimento e consequentemente Exendin-3 (9-39) amide políticas públicas e representatividade política, a autoatribuição pode soar simplista se preestabelecermos que os agrupamentos negros só reafirmam

• TAE226 Although successful conservative management has been

  2019-04-29

  

  Although successful conservative management has been reported [9], the majority require surgical intervention to avoid devastating complications [1,10]. Several groups have demonstrated safety and efficacy of surgical intervention [1,4,10] and operative management may also shorten the length of hosp

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