• A great deal of research

  2021-01-27

  

  A great deal of research has focused on candidate medications to modulate dopaminergic mechanisms through which psychomotor stimulants produce addictive effects, i.e., drugs that expressly target the DA transporter, D1-like receptor, or D2-like receptors., , However, effective dopaminergic-based ph

• One possible explanation for differences in the binding abil

  2021-01-27

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• In the present study we combined activity based protein prof

  2021-01-27

  

  In the present study, we combined activity-based protein profiling, biochemical and genetic approaches to identify the PLCPs involved in the sphingolipid pathway leading to plant PCD. By using Arabidopsis 3-Deazaadenosine and leaves, we demonstrate that this sub-class of plant proteases is activate

• Eukaryotic cell cycle machinery is thought

  2021-01-27

  

  Eukaryotic cell cycle machinery is thought to appropriately modulate cell proliferation and cell expansion in various developmental stages and environmental conditions. The core feature of cell-cycle control is the fluctuation of CDK activity, which is regulated by three interactive and conserved me

• A previous report showed that the transfer of

  2021-01-27

  

  A previous report showed that the transfer of the CSF1 gene into tumor AMG 487 induced TAM infiltration into syngeneic BALB/c mice. High expressions of CSF-1 and CSF-1R in tumor and stromal cells and a high TAM density are known to be correlated with poor prognoses in many cancer types. CSF-1 promo

• Another breakthrough towards the understanding of the mechan

  2021-01-27

  

  Another breakthrough towards the understanding of the mechanisms responsible for stress-induced relapse to drug seeking behaviour is the evidence published by the group of Wise [34] in which they show that the activation of VTA CRF2 and not CRF1 receptors is responsible for stress-mediated relapse t

• Plant uptake of P from OA could also be

  2021-01-27

  

  Plant uptake of P from OA could also be affected by arbuscular mycorrhizal fungi (AMF). Approximately 80% of terrestrial plant species form symbiotic associations with AMF (Smith and Read, 2010) which can enhance plant P uptake (Facelli and Facelli, 2002, Pearson and Jakobsen, 1993, Tibbett, 2000).

• The Fontan circulation When first described in the Fontan op

  2021-01-27

  

  The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital GFP Quantitation Kit mg disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which create

• Although it is well established

  2021-01-27

  

  Although it is well established that estrogen and ESR1 mediate numerous reproductive processes, increasing evidence suggests that ESR2 also lays an integral role in reproduction. ESR2 is a mediator in folliculogenesis and may also act by stimulating ovulation and regulating luteinization (Su et al.,

• br Introduction Cell transplantation therapies using embryon

  2021-01-27

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or AGN 194310 have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups have shown t

• br Acknowledgements Professor Olli A J nne

  2021-01-27

  

  Acknowledgements Professor Olli A. Jänne is warmly thanked for support and for providing excellent research facilities. Professor Patrik Finne is acknowledged for his help with statistical analyses. Drs Ronald Evans, Vincent Giguère, Jorma Palvimo, Malcolm Parker, and Anastasia Kralli are acknowl

• The synthesis of the required substrates is

  2021-01-26

  

  The synthesis of the required substrates is shown in (see for experimental details). Treatment of heterocycle with perk inhibitor under basic conditions afforded a mixture of the mono-substituted product (22%) and the di-substituted compound (38%) which were separated by column chromatography

• It has been reported that the ECD of DDRs require

  2021-01-26

  

  It has been reported that the ECD of DDRs require dimerization and/or oligomerization for binding to collagen.,, Here, we have established using SPR that antibody-mediated oligomerization of DDR2-Fc significantly enhances its binding to immobilized collagen type 1. Our results are consistent with ea

• br Results br Discussion It has been thought that commitment

  2021-01-26

  

  Results Discussion It has been thought that commitment to the plasma cell fate begins while Silicristin synthesis are still in the GC (Suan et al., 2017, Victora and Nussenzweig, 2012), but the main obstacle to test this model and, if correct, to clarify how the plasma cell-prone GC cells dev

• Ubiquitination can occur on a single monoubiquitination

  2021-01-26

  

  Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination). Ub bonds within polyUb chains are formed through 1 of 7 lysine residues in Ub, and the typ

15862 records 698/1058 page Previous Next First page 上5页 696697698699700 下5页 Last page